• Office Hours: Monday-Thursday 9:00am-4:00pm and Friday 9:00am-12:00pm.
  • Our office does not accept insurance of any kind.

Adrenal Stress Index

This is a sensitive and convenient test for measuring the proper functioning of the adrenal glands through a 12 hour day. Based on measuring the concentration of hormones in the saliva, the technique was developed at Harvard in the 1980s and has a very high correlation with free unbound blood serum cortisol.

The adrenals are glands located on top of the kidneys and have four primary functions. They are the primary energy producers of the body; help control inflammation; help balance blood pressure; and help balance blood sugar.

It is well established that the adrenals can become fatigued and dysfunctional in response to prolonged, elevated secretion of cortisol that can result from chronic tissue pain, chronic inflammation, and/or chronic mental or emotional stress. The most prominent sign of adrenal exhaustion or dysfunction is fatigue, although this symptom could also indicate low blood pressure, blood sugar problems, or inflammation that is somewhat out of control. Despite the fact that adrenal dysfunction is very common within Western society, it is not generally recognized by physicians. This is because Western practice focuses on the disease states of either adrenal failure or Addison’s Disease. Both are indicated by very low cortisol levels that are not improved by intravenous stimulation. Diagnosis of adrenal dysfunctions, however, requires tracking an individuals actual diurnal secretion on cortisol, something the stimulation test cannot do.

The adrenals secrete cortisol. The output is very high in the morning and gradually decreases throughout the day. To track this pattern, the Adrenal Stress Index is measured using saliva samples taken at four particular times of the day. The test is done in comparison with DHEA, which is like a companion hormone. The results provide a very good assessment of how strong or weak your adrenals are. Although blood serum could be used in such a test, it would require a patient to visit a lab many times a day, while the saliva test can be self-administered. Numerable tests show that the free cortisol measured in saliva has a 97% correlation with the free cortisol in the blood. This assessment of specific imbalance, dysfunction, or lack of output at particular times of the day allows more specific diagnosis and treatment.

The treatment for adrenal dysfunction is based upon the findings, and is both supportive and physiological. It uses small doses of cortisol large enough to replace what is needed but not large enough to suppress the functions of the gland.

Author: Dr. David Luce

W. David Luce, M.D., P.C. is a Board Certified Internist in private practice in Boulder, Colorado. He is recognized as a innovator and thought leader in the integration of Western medicine with complimentary therapies.

Dr. David Luce | MD

W. David Luce, M.D., P.C. is a Board Certified Internist in private practice in Colorado. He is recognized as a medical innovator, educator, public health advocate, and a leader in the integration of evidence-based Western medicine with complimentary therapies. Educated at Dartmouth, Harvard and Yale, Dr. Luce has over 20 years experience designing and implementing innovative treatment programs that restore health and wellness to his patients. He is a passionate proponent for the use of Western science, not only to prevent disease, but also ...

Read more




What Our Clients Are Saying

“Dr. Luce’s comprehensive approach and attention to my health matters resulted in complete healing. He is my Health Detective.”

JC, Boulder, CO

“It doesn’t take long to know that Dr. David Luce is a compassionate, experienced, gifted man whose professional goal is to guide his patients to good health. It may only take that first office visit as it did for my husband and me over a decade ago…. each of us looking for a physical exam and answers to our health concerns.”

LC & BC, Boulder, CO

“Working with Dr. Luce has been remarkable for me and my family. What is different about his wellness program is how he processes the information available to him. It’s all about me.”

KG, Boulder, CO